Expression of beta-catenin protein APC in ovarian epithelial tumor and its implication
- VernacularTitle:Beta-Cetnin和APC蛋白在卵巢上皮肿瘤中的表达及意义
- Author:
Xiao LIN
- Publication Type:Journal Article
- Keywords:
Ovarian epithelial tumor;
Beta-catenin;
APC protein;
Immunohistochemistry
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of beta-catenin,protein APC and its implication in ovarian epithelial tumor.Methods:Immunohistochemical staining with ABC method was conducted to determine the expression of beta-catenin and protein APC in 48 cases of ovarian epithelial tumors.Results:The rate of beta-catenin in ovarian malignant epithelial tumor was higher than that in benign epithelial tumor,and the rate in borderline epithelial tumor was higher than that in benign epithelial tumor too.There was significant difference between them.The prevalence of protein APC positive in ovarian benign epithelial tumor was significantly greater than that in ovarian malignant epithelial tumor.A significant negative correlation was found between beta-catenin and protein APC in ovarian epithelial tumor.Conclusion:The results suggest that beta-catenin and APC protein have important effects on pathogenesis and development of ovarian epithelial tumors.
