Expression and significance of Clusterin ,bcl-2 and FasL in prostate cancer
- VernacularTitle:Clusterin、bcl-2及FasL在前列腺癌中的表达及相关性研究
- Author:
Gang CHEN
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Apoptosis;
Clusterin;
FasL;
bcl-2;
Immunohistochemistry
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and significance of an inhibitor gene of apoptosis,Clusterin,in prostate cancer,and its relationship with the expression of bcl-2,FasL.Methods:The expression of Clusterin,bcl-2 and FasL in sample of 10 normal prostate,15 BPH and 49 prostate cancer were examined by immunohistochemical stain.Results:The rate of positive or weak positive for normal prostate,BPH and prostate cancer was 10%(1/10),66.6%(10/15)and 91.8%(45/49) respectively.The expression level of Clusterin in prostate cancer was much higher than in normal prostate(P
