Protective effects of polarizing cardioplegia with Na~+ channel inhibitor tetrodotoxin (TTX) on isolated rat hearts
- VernacularTitle:极化停搏液用于离体大鼠心脏保存的实验研究
- Author:
Shuangqiang YANG
- Publication Type:Journal Article
- Keywords:
Polarizing cardioplegia;
Na+ channel inhibitor;
Myocardial protection;
Myocardial preservation
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the protective effects of polarizing cardioplegia with Na+ channel inhibitor tetrodotoxin (TTX) on isolated rat hearts.Methods:While Langendorff and Neely perfusion model were steadily established,the rat hearts(10 hearts in each group)were respectively arrested by depolarizing cardioplegia (St.Thomas No.2 solution ,STH-2)in Group Ⅰ(control group),and by polarizing cardioplegia(TTX)in GroupⅡ.These arrested hearts were preserved in corresponding cardioplegia solution respectively at 7℃ for 5 hours and then underwent 30 minute reperfusion.Pre-ischemia and post-ischemia indexes of the rat hearts were studied,including hemodynamic parameters,myocardial enzymology,ATP content,and ultrastructural changes.Results:There were no differences between two groups before myocardial ischemia.But the recovery of myocardial hemodynamic parameters during reperfusoin in GroupⅡwas better than that in GroupⅠ(P
