Experimental Research on Prevention of Glucocorticoid -induced Avascu lar Necrosis of The Femoral Head with Tongluo Shenggu Capsule
- VernacularTitle:通络生骨胶囊预防激素性股骨头缺血性坏死的药效学实验
- Author:
Jie YUAN
;
Ji LIN
;
Chuanyi XU
;
Qixin YE
;
Yihua XIONG
;
Lin HUANG
;
Hao YUAN
- Publication Type:Journal Article
- Keywords:
Avascular necrosis of the femoral head;
Tongluo Shenggu Capsule;
Prevention
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prevention of glucocorticoid -induced avascular necrosis of the femoral head(ANFH)with Tongluo Shenggu Capsule(TSC).Methods One hundred and twenty adult SD rats were randomized into six groups:normal control group,model group,clofibratum group and three -dose TSC groups(high -,moderate -and low -dose respectively).ANFH rat models were established by injection of glucocorticoid once per week and the med-ication groups were given drugs by ga stric infusion one time a day.The rats were killed in the fourth,eighth and twelfth week respectively.Then the macrosc opic and microscopic feature of the f emoral head were observed,and ink -p erfused specimens of the femoral head were detected and analyzed by auto -photograph software of Metamoph to evaluate the pre-ventive effect of TSC.Results In TSC groups,bone trabecula grew we ll,similar to the normal group;lacu nar bone per-centage was lower than that in the mod el group;fatty degeneration in marrow cavity of the femoral head was redu ced,andthe number of subcartilaginous bloo d vessels and their diameter were increased as compared with those in the model group(P
