Determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Suxing Capsules by HPLC
- VernacularTitle:HPLC测定苏杏胶囊中盐酸麻黄碱和盐酸伪麻黄碱的含量
- Author:
Ruiming WANG
;
Ling ZHANG
;
Yan NI
;
Xia LIU
;
Xianrong LI
- Publication Type:Journal Article
- Keywords:
Suxing Capsules;
ephedrine hydrochloride;
pseudoephedrine hydrochloride;
HPLC;
quantitative determination
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To establish a determination for ephedrine hydrochloride and pseudoephedrine hydrochloride in Suxing Capsules(Herba Ephedrae, Semen Armeniacae Amarum, Fructus Perillal, etc.). METHODS:HPLC with Agilent ZORBAX Extend C_(18) (250 mm?4.6 mm, 5 ?m) column was used. Acetonitrile-0.2% H_3PO_4(5∶95) was used as a mobile phase. The flow rate was 1.0 mL?min~(-1). The detection wawelength was at 210 nm. RESULTS:The methodological evaluation showed that this method had a good repeatability and reproducibility; The average recovery of ephedrine hydrochloride was 99.65% and RSD was 1.6%. The average recovery of (pseudoephedr)ine hydrochloride was 98.90% and RSD was 2.3%. CONCLUSION: This method is simple, quick, accurate and with good reproducibility and can be used for the quality control of Suxing Capsules.
