Significance of platelet rich plasma in promoting bFGF and VEGF expression in would healing of rabbit buns
10.3969/j.issn.1671-8348.2013.35.025
- VernacularTitle:富血小板血浆在促进兔烫伤创面愈合中bFGF VEGF的表达及意义
- Author:
Yixin HU
;
Jie YUAN
;
Yong ZOU
;
Li GUO
;
Bing LIU
- Publication Type:Journal Article
- Keywords:
platelet-rich plasma;
burn wound;
basic fibroblast grow th factor 2;
vascular endothelial grow th factor;
rabbits
- From:
Chongqing Medicine
2013;(35):4297-4298,4301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the significance of platelet rich plasma in promoting bFGF and VEGF expression in would healing of rabbit buns .Methods The 24 rabbits were randomly divided into control group and experimental group .The sulfadiazine silver paint to the wound for control group and the platelet rich plasma gel evenly spread to the wound for experimental group .At 7th ,10th ,14th day ,4 rabbits of each group were randomly selected to sacrificed after anesthesiaed ,wound healing rate was compare in 2 groups ,HE staining and testimmunohistochemistry were conducted in each group .Results At 7th ,10th ,14th day ,the wound healing rate of experimental group were higher than those of control group .At 7th d ,the focal granulation ,cells and vessels inten-sive were more significant in experimental group than in control group ,at 10th day ,the wound fibroblast cells and capillary number are more significant in experimental group ,and at 14th day ,the most of fibroblasts translate into fiber cell and the capillary number decreased ,the fibroblasts proliferation was still active and fiber cell was less in the control group .At 7th ,10th day ,the expression of bFGF and VEGF were both higher ,but experimental group is obvious higher than control group(P<0 .05) ,but at 14th day ,the ex-pression of bFGF and VEGF were gradually declined and was not obvious statistics differences in the two group (P>0 .05) .Conclu-sion The platelet rich plasma could promote the big white rabbit scald wound healing ,while the main mechanism maybe the ex-pression of bFGF and VEGF increased in the early .
