Effects of glucagon-like peptide 2 on the absorption-related genes expressionsof residual small bowel in a rat model of short bowel syndrome
- VernacularTitle:胰高血糖素样肽-2对短肠大鼠残留小肠吸收功能基因表达的影响
- Author:
Ji CHEN
;
Hang LI
;
Guohao WU
- Publication Type:Journal Article
- Keywords:
Short bowel syndrome;
Glucagon-like peptide 2;
Sodium dependent glucose transporter 1;
Dipeptide transporter
- From:
Chinese Journal of Digestion
1996;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of glucagon-like peptide 2 (GLP-2) on the absorption- related genes [ sodium dependent glucose transporter 1 (SGLT1) and dipeptide transporter 1 (PEPT1)] mRNA expressions of residual small bowel in a rat model of short bowel syndrome. Methods Rats undertaken 75% small bowel resection were randomly assigned into 3 groups: short bowel control (SBC) group, growth hormone (GH) group and GLP-2 group. Another weight-matched normal rats with normal diet was used as normal (NC) group. All rats were given normal chow on the 1st postoperative day (POD). On the 6th POD, partial segment of terminal ileum was harvested to evaluate the mRNA expressions of SGLT1 and PEPT1 by semiquantified reverse transcription polymerase chain reaction. Results The mRNA expressions of both SGLT1 and PEPT1 in SBC group were significantly higher than that of NC group(P0.05). Conclusions A short term GLP-2 adiministration in early postoperative days may has no significant effect on mRNA expressions of SGLT1 and PEPT1 in residual ileum in rats with short bowel syndrome.
