Effects of hyperbaric oxygen on the expression of NF-?B and ICAM-1 after focal cerebral ischemia-reperfusion in rats
- VernacularTitle:高压氧对脑缺血再灌注大鼠核因子-?B及细胞间粘附分子-1表达的影响
- Author:
Jiang XU
;
Xiaolin HUANG
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia;
Hyperbaric oxygen;
NF-?B;
ICAM-1;
Rat
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of hyperbaric oxygen (HBO) on the expression of NF-?B and ICAM-1 after cerebral ischemia-reperfusion in rats. Methods The middle cerebral artery occlusion-reperfusion (MCAOR) model was established by using Zea-Longas method in rats. Seventy-two rats were recruited in this study and randomly divided into 3 groups: a cerebral ischemia-reperfusion group (CIR group),a CIR+HBO group(HBO group),and a sham-operation group(SO group). The infarct volume of each group was measured by TTC staining technique, and the expression of NF-?B and ICAM-1 was measured at 24 h, 48 h, 72 h and 120 h, respectively, after reperfusion by using immunohistochemistry staining. Results The infarct volume in HBO group was significantly smaller than that in CIR group (P
