A Case of Secondary Cutaneous Diffuse Large B-Cell Lymphoma.
- Author:
Jung Keun KIM
1
;
Tack Hun KIM
;
Tae Ho PARK
;
Jae Hak YOO
;
Kea Jeung KIM
Author Information
- Publication Type:Case Report
- Keywords: Bcl-2; Post-GC B-cell; Secondary cutaneous diffuse large B-cell lymphoma
- MeSH: Aged; Antibodies, Monoclonal; B-Lymphocytes*; Cheek; Cisplatin; Classification; Dermis; Drug Therapy; Humans; Lymph Nodes; Lymphocytes; Lymphoma; Lymphoma, B-Cell*; Neck; Pneumonia; Skin; World Health Organization
- From:Annals of Dermatology 2006;18(2):91-96
- CountryRepublic of Korea
- Language:English
- Abstract: We report here on a case of secondary cutaneous diffuse large B-cell lymphoma (DLBCL) that occurred in a 67-year-old man who had a 2-month history of nodular growing masses on the left cheek, plus palpable lymph nodes on the left cervical area. The histopathological findings showed a diffuse infiltration of large atypical lymphocytes with nuclear atypia throughout the entire dermis. These showed positive CD20, bcl-2 and the post-germinal center marker, MUM-1. According to the WHO (World Health Organization) classification, this lymphoma is considered to be diffuse large B-cell lymphoma of the post-germinal center (GC) B-cell type with a secondary cutaneous manifestation. We treated the patient with systemic chemotherapy (CHOP) and anti-CD20 monoclonal antibodies. During the course of treatment, new skin lesions developed on his neck, so we changed the regimen to cytosin- arabinoside and cisplatin. But he died of pneumonia after the third cycle.
