Polymorphism in insulin receptor gene exon 17 in women with polycystic ovary syndrome
- VernacularTitle:多囊卵巢综合征患者胰岛素受体基因外显子17的多态性研究
- Author:
Li JIN
;
Hefeng HUANG
;
Fan JIN
;
Yuli QIAN
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Receptor, insulin;
Polymorphism, single-stranded conformational;
Insulin resistance
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate insulin receptor (INSR) genotype exon 17 frequencies in women with polycystic ovary syndrome(PCOS) and to elucidate its role in the pathogenesis of PCOS. Methods The study involved 33 women with PCOS and 28 healthy control women who were genotyped for polymorphism of INSR gene exon 17 by single strand conformation polymorphism (SSCP) analysis. Body mass index (BMI), insulin sensitive index (ISI), the expression of INSR beta subunit, and serum concentration of luteinizing hormone(LH), total testosterone between the genotypes were compared. Results (1) The T -to- C mutation was observed in the INSR gene exon 17 (1008 bp). The frequency of the C/C genotype was significantly higher in patients (39%) than in the controls (11%) (P
