Relative bioavailability of Ophiopogon japonicus saponin enteric microsphere in rats
- VernacularTitle:液质联用研究麦冬皂苷肠溶微球在大鼠体内的相对生物利用度
- Author:
Lan SHEN
;
Desheng XU
;
Yi FENG
;
Linghai JIANG
;
Yumin LIU
;
Yijian LAI
- Publication Type:Journal Article
- Keywords:
Ophiopogon japonicus saponin enteric microsphere;
relative bioavailability;
HPLC-MS;
solid phase extraction
- From:
Chinese Traditional and Herbal Drugs
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relative bioavailability after ig rats with Ophiopogon japonicus saponin enteric microsphere in single-dose so as to give directly preparation quality evaluation. Methods(Establishing the) analysis method of HPLC-MS and dealing with the blood sample by solid phase extraction. Determining the diosgenin concentration in plasma after ig Ophiopogon japonicas saponin enteric microsphere and the suspension as comparison in single-dose, and calculating pharmacokinetic parameters and relative bioavailability. Results C_(max), t_(max), and AUC_(0-72) were (637.81?17.23) ng/mL, (4.0?0.0) h, and 7 840.01?412.03, respectively. Conclusion The characteristics of absorption, distribution, and elimination are resembled in rats between two preparations by ig in single-dose. The pharmacokinetic parameters are also identical. The relative bioavailability is (91.10?3.44)%.
