Effect of Buyang Huanwu Decoction on expression of adhesion molecules in vascular endothelial cells of blood stasis rats
- VernacularTitle:补阳还五汤对血瘀证大鼠血管内皮细胞黏附分子表达的影响
- Author:
Liguo CHEN
;
Yuan QU
;
Hongying GE
;
Xiaoqin HU
;
Youai NIE
;
Mengqi HE
- Publication Type:Journal Article
- Keywords:
blood-stasis;
vascular endothelial cells (VECs);
Buyang Huanwu Decoction (BHD);
(adhesion) molecules;
immunohistochemical method;
RT-PCR
- From:
Chinese Traditional and Herbal Drugs
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Buyang Huanwu Decoction (BHD) on adhesion molecules in vascular endothelial cells (VECs) of blood stasis rats. Methods Expression of ICAM-1, VCAM-1, PECAM-1, iNOS in vascular endothelial cells of blood stasis rats receiving different doses of BHD was observed by immunohistochemical method and RT-PCR.Results The expression of ICAM-1, VCAM-1, PECAM-1, iNOS was increased in model group, while was decreased by BHD. There was an increase tendency on the expression of molecules and significant dose-effect relationship along with the decrease of the BHD doses. Conclusion The increased expression of adhesion molecules in vascular endothelial cells of blood stasis rats could be reduced by BHD in a dose dependent manner.
