Effect of Salvia miltiorrhiza extracts on morphine physical dependence in mice
- VernacularTitle:丹参提取物对小鼠吗啡身体依赖性的影响
- Author:
Hongqiang QIU
;
Chonghong CHEN
;
Juan YU
- Publication Type:Journal Article
- Keywords:
Salvia miltiorrhiza Bunge extracts;
morphine dependence;
withdrawal symptom
- From:
Chinese Traditional and Herbal Drugs
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Salvia miltiorrhiza extracts on morphine physical dependence in mice. Methods The physical dependence model was induced by repeated sc morphine daily in mice and then withdrawal symptom was induced by ip naloxone. Different doses of S. miltiorrhiza extracts were administrated by ip during or after the induction phase of morphine dependence, and effects of S. miltiorrhiza extracts both by preventive and acute administration on naloxone-precipiated withdrawal symptom in mice were investigated. The potential physical dependence of S. miltiorrhiza extracts was studied. Results Compared to morphine model group, preventive administration of S. miltiorrhiza extracts (100—200 mg/kg) could reduce the number of naloxone-induced withdrawal jumps (P
