Protective effect of shenfu preconditioning on myocardium against ischemia-reperfusion injury in rats
- VernacularTitle:参附注射液预干预对大鼠心肌缺血/再灌注损伤的保护作用
- Author:
Yupei CHEN
- Publication Type:Journal Article
- Keywords:
Shenfu;
Myocardial ischemia/reperfusion injury;
Hemodynamics;
Heat shock protein
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between the protective effect of shenfu parenteral solution (SF) on myocardium in rats and HSP 70 .Methods:To establish general ischemia reperfusion(I/R) model.Thirty-five healthy white rats were divided into five groups randomly:sham operation group(group C),I/R30 group (including 2 groups),SF group(including 2 groups).After myocardial ischemia lasting for 40min,then reperfusing for 30min or 120min.To detect hemodynamic parameter,myocardium MDA content,SOD activity,HSP 70 expression and ultrastructure were examined.Results:Compare with I/R group:LVSP and ?dp/d/max rose up,however,LVEDP decreased( P
