An experimental research in rat model of middle cerebral artery occlusion using ~1H MRS
- VernacularTitle:大鼠脑缺血后~1H磁共振波谱分析的实验研究
- Author:
Renlan ZHOU
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia;
Middle cerebral artery occlusion;
1H magnetic resonance spectroscopy
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).NAA reached the lowest level at 24hours and Ch and Cr at 3days,and then NAA,Ch and Cr gradually increased with time.The increase in NAA was especially obvious which increased by 1.5 times at 2 months than that at 24hours after cerebral ischemia.The earliest detection of lactate was at 10 minutes within the infarct.The lactate concentration elevated and peaked at 12 hours,and a partial recovery of the reduction of lactate was seen at 3 days.However,the elevation in lactate was no longer observed during the period of up to 2 month follow-up.Conclusion:(1) 1HMRS can early detect the metabolite changes induced by middle cerebral artery occlusion in rats.(2).Abnormalities in chronic stage of cerebral ischemia in rats could also be found and gave important information for evaluating neuroprotective strategies.
