Clinical comparative study of simvastatin, xuezhikang and pravastatin in common doses on primary hyperlipidemia
- VernacularTitle:临床常用剂量下的舒降之、血脂康、美百乐镇对原发性高脂血症调脂作用的比较
- Author:
Lihua LI
- Publication Type:Journal Article
- Keywords:
Hyperlipidemia;
Simvastatin;
Xuezhikang;
Provastatin
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effects of simvastatin,xuezhikang and pravastatin in patients with primary hyperlipidemia.Methods:Sixty patients were randomly divided into three groups,simvastatin 20mg were taken once a day at night;provastatin 10mg were taken once a day at night;xuezhikang 0.6g were taken twice a day in the morning and at night.Blood samples were taken before and 4 weeks,8 weeks,12 weeks after the treatment.Results:In simvastatin group:the serum levels of total cholesterol(TC),low-density lipoprotein cholesterol(LDL C) decreased markedly at the end of 4 weeks compared with those of the baseline ( P 0.05).In xuezhikang group:after 4 weeks of treatment,TC,TG,LDL C reduced markedly( P 0.05).From the change rates,we can see after 8 weeks,12 weeks of treatment the level of LDL C drcreased more significantly in simvastatin group (40%,45%) than in xuezhikang (31%,36%) and provastatin (31%,35%) ( P 0.05).Conclusion:The clinical effects of simvastatin,xunzhikang,provastatin on primary hyperlipidemia were equal among the three groups,but the time is different about when they take great effects respectively.Next,LDL C lowering effect of simvastatin was significant.Finally,xuezhikang was the best in reducing TG among the three groups and it has a relatively good economic effectiveness.
