Synergistic suppressive effects of matrine and 5-fluorouracil on growth of implanted gastric cancer in nude mice
- VernacularTitle:苦参碱联合5-氟尿嘧啶对人胃癌裸鼠移植瘤的抑制作用
- Author:
Meijie HU
;
Hui ZENG
;
Yongping ZHANG
- Publication Type:Journal Article
- Keywords:
Matrine;
5-fluorouracil;
Stomach neoplasm;
Bone marrow inhibition
- From:
Chinese Journal of Digestion
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of matrine in combination with 5-fluorouracil (5-FU) on inhibiting transplanted gastric cancer (cell line SGC-7901) in the nude mice and their myelotoxicity effects. Methods The two dosages of matrine (50 mg/kg and 100 mg/kg) combined respectively with 50 mg/kg of 5-fluorouracil (5-FU) were injected intra-abdominally, and 50 mg/kg or 100 mg/kg matrine or 5-FU injection alone groups served as controls. The relative tumor volume (RTV) and tumor inhibition rate (IR) were calculated. The nude mice bone marrow was taken, the number of the nucleated cells were calculated, and bone marrow colony was cultured. Results The tumor-inhibiting effect in the combined group of 100 mg/kg of matrine +50 mg/kg of 5-FU was significantly increased as compared with those in all the control group ( P
