Effects of basic fibroblast growth factor and sucralfate on healing of experimental gastric ulcers in rats
- VernacularTitle:成纤维细胞生长因子与硫糖铝对大鼠实验性胃溃疡的治疗作用
- Author:
Youxiang CHEN
;
Wei HU
- Publication Type:Journal Article
- Keywords:
Basic fibroblast growth factor;
Sucralfate;
Gastric ulcer;
Theraputic effect
- From:
Chinese Journal of Digestion
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of basic fibroblast growth factor(bFGF)and sucralfate on healing of experimental gastic ulcer in rats. Methods Thirty-two famale Sprage-Dawley rats were divide into 4 groups,averagely.bFGF 100 ng?100 g -1 ?d -1 , sucralfate 40 mg?100 g -1 ?d -1 , bFGF 100 ng?100 g -1 ?d -1 + sucralfate 40 mg?100 g -1 ?d -1 and normal saline were used in experimental gastric ulcer rats induced by acetic acid for 21 days. Contents of gastric acid and pepsin were measured,and the healing rate and quality of gastric ulcer and the number of capillaries in ulcer bed were evaluated. Results The amount of gastric acid and pepsin in bFGF group had no different from those of normal saline group. The ulcer areas in bFGF group and sucralfate group were (2.9 ?0.8) mm 2 and (3.2?1.2) mm 2 respectively,which were significantly smaller than that of normal saline group (6.8? 1.4 ) mm 2, P
