Assessment of Left Ventricular Diastolic Function in Mild to Moderate Hypertension by Radionuclide Ventriculography.
10.4070/kcj.1987.17.3.401
- Author:
Myung Ho JEONG
;
Sang Jin PARK
;
Seung Gwan KIM
;
Jong Chun PARK
;
Jung Chaee KANG
;
Ock Kyu PARK
;
Hee Seung BOM
;
Ji Yeul KIM
- Publication Type:Original Article
- MeSH:
Blood Pressure;
Heart Ventricles;
Humans;
Hypertension*;
Radionuclide Ventriculography*;
Sodium Pertechnetate Tc 99m;
Ventricular Dysfunction, Left
- From:Korean Circulation Journal
1987;17(3):401-409
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To determine whether are significant diastolic left ventricular dysfunctions in mild to moderate hypertensive patients with normal systolic function, radionuclide ventriculography by in vivo red cell labelling technique using 20 mCi of (99m)Tc pertechnetate was performed in 24 hypertensive patients(mean age: 50.6+/-12.4, mean blood pressure: 156.9+/-11.8/100.6+/-7.1 mmHg) and in 11 normal subjects (mean age: 42.7+/-13.5, mean blood pressure: 123.2+/-6.8/82.3+/-3.9 mmHg). The results were as follows: 1) Ejection fraction was similar in both hypertensive and control groups (0.70+/-0.06 versus 0.70+/-0.08). 2) Mean of the peak filling rate (PFR) was significantly lower in hypertensive group (2.07+/-0.45 EDV/sec) than in control group (2.42+/-0.30 EDV/sec) (p<0.05). 3) Mean of the time to peak diastolic filling (TPDF) in hypertensive patients was 189.0+/-30.4 msec and which was significantly longer than that of control subjects (164.5+/-22.4 msec)(p<0.02). 4) Mean of the first third filling fraction (1/3 FF) in hypertensive patients was 0.22+/-0.07 and which was significantly lower than that of control subjects (0.32+/-0.09)(p<0.01). 5) Decreased PFR and delayed TPDF were also demonstrated with advances in age in both groups. Above results suggest that the diastolic evaluation of left ventricle might be necessary in the hypertensive patients with normal systolic function, and that diastolic dysfunction may precede the systolic dysfunction and clinical deterioration.
