Correlation study on serum Ig levels and adult patients with immune thrombocytopenia

VernacularTitle:血清免疫球蛋白水平与成人IT P患者疗效的相关性研究
Author: Jun SONG ; Yunfen CHEN ; Pengxiang GUO ; Hongqian ZHU ; Qing WANG ; Chi CHEN
Publication Type:Journal Article
Keywords: immune thrombocytopenia; treatment strategies; Ig
From: Chongqing Medicine 2013;(31):3771-3772,3775
CountryChina
Language:Chinese
Abstract: Objective To investigate whether the Serum Ig is help to choose the optimal treatment in patients with immune thrombocytopenia(ITP) .Methods 128 ITP patients were collected for 3 years .All of ITP patients were treated with the step-style protocol including glucocorticoid(CsA)lombied IVIG ,Ciclosporin A and TPO receptor agonist lombied rituximab .The treatment re-sponse were evaluated according the comparison between the two groups namely ≤IgG ,IGM ,IgA median and > median groups . Results There was no relationship between the bleeding and IgA 、IgM、IgG level .Low IgM level was associated with first line treatment resistance and showed the response to CsA and TPO receptor agonist lombied rituximab .High IgA level was associated with the resistance of first line and CsA treatment ,but showed no response to TPO receptor agonist lombied rituximab .Conclusion Serum Ig level is helpful for the choice of optimal treatment strategies in adult IT P patients .