Effect of Electroacupuncture on Synaptic Transmission in Hippocampal Dentate Gyrus of Rats with Cerebral Ischemic Damage
- VernacularTitle:电针对缺血性脑损伤大鼠海马齿状回突触传递活动的影响
- Author:
Zhuoxin YANG
;
Haibo YU
;
Ling WANG
;
Min PI
;
Jiawei ZHANG
- Publication Type:Journal Article
- Keywords:
CEREBRAL ISCHEMIA/acup-mox therapy;
HIPPOCAMPUS /acup-mox effects;
SYNAPTIC TRANSMISSION;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[ Objective ] To investigate the effect of electroacupuncture ( EA) on synaptic transmission in hippocampal dentate gyrus of rats with cerebral ischemic damage. [Methods] Sixty Wistar rats were enrolled into this study. Among them, 30 were given high-frequency stimulation (HFS) and the other 30 were not. Then the HFS rats were randomized into sham-operation group (group A), model group (group B) and acupuncture group (group C); so did the non-HFS rats. Bilateral carotid arteries were exposed but not blocked in Group A, while were blocked by traction with silk thread for modeling in group B. Group C were treated with EA before and after modeling. Effects of EA on synaptic transmission in hippocampal dentate gyrus of non-HFS rats were evaluated with in-vivo long-term potential ( LTP) recorded by electrophysiological technique. Effects of EA on LTP in hippocampal dentate gyrus of HFS rats were observed after LTP was induced by HFS. [Results] In non-HFS rats, no significant changes of magnitude of population spike (PS) occurred within 120 min in group A; magnitude of PS in group B decreased at 10th min after modeling ( P
