Correlation between release rate in vitro and adsorption in vivo of Shenshen sustained-release Capsule
- VernacularTitle:肾参缓释胶囊体外释放与体内吸收的相关性研究
- Author:
Yulan WANG
;
Xin LUAN
- Publication Type:Journal Article
- Keywords:
Shenshen sustained-release Capsule;
sustaiued-release;
in vitro/in vivo;
correlation;
rat
- From:
Chinese Traditional Patent Medicine
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the correlation between the release rate in vitro and the absorption in vivo of Shenshen sustained-release Capsule(SSRC phenylethanoid glycosides). METHODS: Release rate of SSRC in vitro was tested with D-800LS dissolution tester. 8 rats were randomly divided into two groups. One group was orally fed on SSRC. Plasma levels were determined by UV and the absorption fraction was calculated according to Wagner-Nelson's formula. RESULTS: The correlation coefficient between the release rate in vitro and the absorption fraction in vivo was 0.9654 . CONCLUSION: There is a significant correlation between release rate in vitro and absorption in vivo to SSRC.
