Study on the level of placental urocortin and corticotropin-releasing hormone receptor 2? of preeclampsia
- VernacularTitle:胎盘组织中尿皮素和促肾上腺皮质激素释放激素2?受体表达变化与先兆子痫发病的关系
- Author:
Zhaoxia CHENG
;
Tao SHANG
;
Li ZHANG
- Publication Type:Journal Article
- Keywords:
Pre-eclampsia;
Corticotropin-releasing hormone;
Receptors, corticotropin-releasing hormone;
Placenta
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the relation between the expression of urocortin and corticotropin-releasing hormone receptor 2? (CRH-R2?) in the placenta and pathogenesis of preeclampsia. Methods Placentas were collected from 20 pregnant women with preeclampsia as study group and 20 normal pregnant women as control group. Urocortin mRNA and CRH-R2? mRNA were measured by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR). Urocortin peptide was measured by immunohistochemistry. Results (1) The mRNA expression of urocortin was significantly higher (P
