A new quinolone alkaloid with antibacterial activity from Lappula echinata
- VernacularTitle:东北鹤虱中一个具有抗菌活性的新喹酮类生物碱
- Author:
Shaoyu ZHANG
;
Lin MENG
;
Wenyuan GAO
;
Wei JIA
;
Hongquan DUAN
- Publication Type:Journal Article
- Keywords:
Lappula echinata Gilib.;
NMR spectrum;
quinolone;
antibacterial activity
- From:
Chinese Traditional and Herbal Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the chemical constituents of Lappula echinata and determine the antibacterial activity.Methods A new quinolone alkaloid was isolated from the BuOH extract of L.echinata by silica gel column chromatography and gel column chromatography.Its structure was identified by 1H-NMR, 13C-NMR, 2D-NMR, HR-MS, UV, and IR spectral data analysis.Its antibacterial activity was determined by KB method.Results A new quinoloe alkaloid named 8-methoxy-4-quinolone-2-caboxylic acid was isolated from L.echinata and was found to have antibacterial activity on Pseudomonas pyocyanea ATCC 27853, EPEC O111, pneumobacillus and Staphylococcus epidermidis.Conclusion This is a new compound with antibacterial activity.
