EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE AND HEME OXYGENASE-1 IN HUMAN COLON OF IRRITABLE BOWEL SYNDROME
- VernacularTitle:诱导型一氧化氮合酶与血红素氧合酶在人肠易激综合征结肠中的表达
- Author:
Qizhi WANG
;
Ming ZHANG
;
Youfa ZHU
;
Mei ZHANG
;
Min GAO
;
Jianwei PAN
;
Tianrong REN
- Publication Type:Journal Article
- Keywords:
Irritable bowel syndrome;
Inducible nitric oxide synthase;
Heme oxygenase-1;
Immunohistochemistry;
Human
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of inducible nitric oxide synthase (iNOS) and heme oxygenase-1(HO-1) in human colon of irritable bowel syndrome(IBS), aim at finding out the role of gas messenger molecule such as nitric oxide(NO) and carbon monoxide(CO) in the pathogenesis of IBS. Methods The expression of iNOS and HO-1 in human colonic tissue specimen of enteroscope was detected by En vision and SABC immunohistochemistry each in 34 cases of IBS and 16 cases of normal control group. Results The expression of iNOS and HO-1 expressed mainly in the colonic mucous membrane epithelia, and the expression in IBS group was higher than that in normal control group(P
