Effect of gestrinone on the lipid metabolic parameters and bone mineral density in patients with endometriosis
- VernacularTitle:孕三烯酮对子宫内膜异位症患者脂代谢及骨密度的影响
- Author:
Ping ZHENG
;
Yufang ZHANG
;
Jiandong WANG
- Publication Type:Journal Article
- Keywords:
Gestrinone;
Endometriosis;
Bone density;
Gonadal steroid hormones;
Lipids
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Obstetrics and Gynecology Hospital, Capital University of Medical Science, Beijing 100026, ChinaAbstract Objective To observe the change of lipid metabolic parameters, sex hormone and bone mineral density(BMD) in patients with endometriosis before and after oral administration of gestrinone. Methods Fifty-six patients with endometriosis, aged from 20 to 45, were treated with gestrinone 2.5 mg two times a week for 6 months one week after operation. Serum total cholesterol(TC),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol(LDL-C),ApoA_1,ApoB,follicle stimulating hormone (FSH), luteinizing hormone(LH),E_2 and BMD were determined before taking gestrinone, after taking for 6 months and withdrawal for 6 months. Results After administration of gestrinone for 6 months, serum HDL-C and ApoA_1 decreased significantly (P
