Study of Fc?RⅢA-158F/V polymorphism in patients with rheumatoid arthritis
- VernacularTitle:类风湿关节炎患者Fc?RⅢA多态性研究
- Author:
Jiong ZHANG
;
Hejian ZOU
- Publication Type:Journal Article
- Keywords:
Receptors, IgG;
Arthritis, rheumatoid;
Polymorphisms
- From:
Chinese Journal of Rheumatology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study is to confirm the putative association between the Fc?RⅢA-158F/V allele and rheumatoid arthritis (RA) by genotyping the Fc?RⅢA-158F/V polymorphism in patients and controls. Methods One hundred and ninety-two RA patients were recruited and all patients fulfilled the American College of Rheumatology 1987 revised criteria for RA. The demographic data including age, sex and disease duration were collected. The 192 RA patients and 179 control subjects were genotyped for Fc?RⅢA-158F/V polymorphism with a reliable polymorphism assay, nested PCR to investigate whether the Fc?RⅢA-158F/V polymorphism was a risk factor for RA. Results The frequency of Fc?RⅢA-158V/V homozygous was higher in RA patients (OR=3.1, P
