Establishment of experimental animal model of pristane induced rheumatoid arthritis in rats
- VernacularTitle:降植烷诱导大鼠类风湿关节炎模型的建立
- Author:
Yan LIU
;
Miaona JIANG
;
Yujie JIA
- Publication Type:Journal Article
- Keywords:
Arthritis, rheumatoid;
Models, animal;
Autoimmunity
- From:
Chinese Journal of Rheumatology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The animal model of rheumatoid arthritis was established in Lewis rats by a single intradermal injection of pristane. Methods The degree of pathogenicity and the pathological characteristics were assayed by histiopathological techniques and joint roentgenography. Results The incidence of arthritis in rats immunized by pristane was 62.5%. Peripheral joints were mainly involved. A chronic relapsing and progressive arthritis was developed.As showed by histopathology and roentgenography, typical arthritis pathology such as synovial proliferation, articular cartilage and bone erosien were found. Conclusion Pristane induced arthritis mirrors human rheumatoid arthritis and is a very good animal model for rheumatoid arthritis.
