The study of genome DNA methylation in systemic lupus erythematosus
- VernacularTitle:系统性红斑狼疮患者基因组DNA甲基化水平的初步研究
- Author:
Xiaoyan XU
;
Weihua ZHOU
;
Chuanshi XIAO
;
Xiaofeng LI
;
Laiyuan WANG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
DNA methylation;
S-Adenosylmethionine;
S-Adenosylhomocysteine;
Methylenetetrahydrofolate dehydrogenase
- From:
Chinese Journal of Rheumatology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the genome DNA methylation in SLE and the related factors of DNA methylation. Methods Twenty-six cases with SLE and 20 controls were recruited to participate the study. Plasma Hcy, SAM, SAH and the MTHFR gene C677T polymorphism were measured in all patients and controls. Results {1} The SAM levels were lower significantly in SLE groups than in controls. The SAH levels were higher significantly in SLE groups than in controls. {2} There was significant inverse correlation between plasma Hcy level and SAM level (r=-0.897, P
