Changes of Circulating Immune Complex in Monkeys Infected by Simian Immunodeficiency Virus
- VernacularTitle:艾滋病病毒感染猴的循环免疫复合物的变化
- Author:
Hongmei WO
;
Wendi DENG
;
Song CHEN
;
Xiaoxian WU
;
Lichun FU
- Publication Type:Journal Article
- Keywords:
SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME;
ANTIGEN-ANTIBODY COMPLEX;
DISEASE MODELS, ANIMAL;
MACACA MULATTA;
MACACA FASCICULARIS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the dynamic changes of circulating immune complex (CIC) in monkeys infected by simian immunodeficiency virus (SIV). [Methods] Agglutination test of complement-sensitized yeast cell was used to determine the serum CIC level in 30 cases of monkeys, which were infected with SIVmac251 and sampled in different time-points after infection. Sixty-eight cases of normal monkeys were also examined as controls. [Results] After SIV infection, CIC can't be detected in all 30 monkeys until the 4th week, the total positive rate being 30% . In the 8th week, CIC were detected in 46.7% of these monkeys and then declined gradually in the following 12 weeks. Since the 20th week, the CIC in these monkeys maintained lower liter and lower positive rate which was close to that of the normal monkeys (about 10%). [Conclusion] CIC appeared and increased during the primary SIV infection and declined accompanying with the virus clearance from the circulalion. The formation of CIC may not benefit to the control of virus replication and the induction of anti-virus immunity; CIC has a role in the pathogenesis after SIV infection.
