Pharmacokinetic Study on Ferulic Acid in Plasma of the Healthy Female Volunteers after Oral Administration of Shenghua Decoction
- VernacularTitle:健康女性志愿者口服生化汤后血清中阿魏酸的药动学研究
- Author:
Yanmei WANG
;
Hengjun SHI
;
Xi HUANG
;
Baoxiu WANG
;
Hongquan GAN
- Publication Type:Journal Article
- Keywords:
ferulic acid;
Shenghua decoction;
female;
pharmacokinetics;
RP-HPLC
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics of ferulic acid (FA) in plasma of the healthy female volunteers after oral administration of Shenghua decoction.Methods Using p-hydroxybenzaldehyde as the internal standard, the plasma concentration of FA was determined by RP-HPLC. Plasma samples were extracted and treated with boiling water and 3P97 programme was used to calculate the pharmacokinetic parameters. Results The main pharmacokinetic parameters of FA were as follows: T1/2?=18.72 min ,T1/2?=79.21 min,T1/2 Ka=11.19 min,AUC=18004.87 ?g?min?L-1,CL=0.17L?min-1?kg-1,Cmax=206.30 ?g?L-1, Tpeak=22.78 min.Conclusion After oral administration of Shenghua decoction, FA could be absorbed and eliminated rapidly and pharmacokinetics of FA conforms to a two-compartment open model.
