The role of ribosomal S6 kinase in the pathogenesis of rat hepatic fibrosis
- VernacularTitle:核糖体S6激酶与大鼠肝纤维化相关性研究
- Author:
Miaofang YANG
;
Xin ZHANG
;
Hui QIANG
- Publication Type:Journal Article
- Keywords:
Hepatic fibrosis;
Hepatic stellate cell;
Ribosomal S6 kinase
- From:
Chinese Journal of Digestion
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of ribosomal S6 kinase (RSK) in the pathogenesis of rat hepatic fibrosis. Methods Intra-abdominal injection of dimethylnitrosamine was carried out to (establish) the model of rat experimental hepatic fibrosis. Immunofluorescent double labeling laser scanning (confocal) microscope was performed to detect the location of RSK, ?-smooth muscle actin(?-SMA) and the collagen type Ⅰ. Immunohistochemistry was used to determine the correlation of the expression of RSK and collagen type Ⅰ, Ⅲ in the tissue of hepatic fibrosis. Results In the tissue of hepatic fibrosis, RSK was coexpressed with ?-SMA, and the collagen type Ⅰ located around RSK. The expression of RSK was also correlated with that of collagen type Ⅰ and Ⅲ( P
