Experimental study on acoustic environment change in normal rabbit liver tissue with HL-1(Ⅱ)
- VernacularTitle:HL-1改变兔肝脏组织声学环境的实验研究(Ⅱ)
- Author:
Yanbing XIAO
- Publication Type:Journal Article
- Keywords:
HL-1;
Rabbit liver;
Acoustic environment in tissue (AET);
Focused ultrasound (FU);
Temperature rising;
Density
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the feasibility and mechanism on changing acoustic environment in tissue (AET) of rabbit liver by HL-1 intravenous injection.Methods:10 New Zealand rabbits were randomly divided into two groups,treatment and control group with 5 rabbits respectively.Before rabbit livers were ablated in vitro by using focused ultrasound(FU)(3.04W,11MHz),HL-1 was injected intravenously via rabbit ear marginal vine for 20 minutes.Rabbits were sacrificed by excessive anesthesia after 1 hour,and small pieces of liver tissue were cut for pathological exammation.Rabbits liver were ablated with FU in the manners of dot scan in different preplanned liver areas with various treatment time of 3s,6s,9s,12s and 15s,and its temperature in each dot was measured immediately after ablation.2 to 3 pieces of non-damaged tissues in each liver were chosen to measure its density after trial.All processes were the same as those of experiment group except replacing HL-1 with saline in control group.Results:Similar time-temperature curve showed in two groups except the temperature was higher in every dot in treatment group than that of control group( P
