The effect of Astragalus injection on CCl_4-ethanol-induced rat hepatic fibrosis
- VernacularTitle:黄芪注射液对CCl_4诱导的大鼠肝纤维化的防治
- Author:
Xian ZHOU
- Publication Type:Journal Article
- Keywords:
Hepatic fibrosis;
Astragalus injection;
HA;
LN;
Antioxidant
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the inhibitive effect of Astragalus injection on CCl 4-ethanol-induced hepatic fibrosis.Methods:40% CCl 4 and 5% ethanol were used to induce hepatic fibrosis.Astragalus injection group:Astragalus injection(800mg/kg?d) was administered during formation of inducing hepatic fibrosis.Model control group only received saline.After 7 weeks,all groups were compared in terms of serum examinations(HA,LN) and liver tissue examinations(change of histology,degree of hepatic fibrosis,level of SOD and MDA,and immunohistochemistry of LN).Results:Compared with model control group,treatment of rats with Astragalus injection remarkably decreased serum HA and LN levels( P
