Association between TGF-?_1 in allograft and chronic allograft nephropathy
- VernacularTitle:移植肾转化因子?与慢性移植肾肾病关系的研究
- Author:
Pingxian WANG
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Nephropathy;
TGF-?_1
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the relation between transforming growth factor ? 1 (TGF-? 1)in allograft and chronic allograft nephropathy (CAN).Methods:Urine TGF-? 1 relative concentration(divided by urine creatinine) was tested in 181 recipients whose renal function were normal between August 1,2000 and June 31,2001.25 cases with higher urine TGF-? 1 relative concentrations were assigned to group A,other 25 cases with lower urine TGF-? 1 to group B.In both groups biopsies were carried out in 16 cases and 13 cases respectively.TGF-? 1 mRNA in the biopsis was tested by RT-PCR.Blood TGF-? 1 concentrations in the two groups were also tested.Three years later,the renal function was compared between the two groups.The correlation between expression of TGF-? 1mRNA and long-term renal function was determined.Biopsies were carried out in renal recipients whose creatinine was higher than normal.Results:Blood TGF-? 1 concentrations in the two groups were not significantly different,3 years after transplantation,there was more loss of renal function and larger number of chronic allograft nephropathy (CAN) cases in group A than group B.Expression of TGF-? 1mRNA in the allografts was found more in group A than in group B.The difference in the two groups was significant.There was a correlation between expression of TGF-? 1mRNA and long-term renal function.Conclusion:The findings suggest expression of TGF-? 1mRNA in the allografts is associated with chronic allograft nephropathy.The level of urine TGF-?_1 after renal transplantation can predict long-term renal function.
