Influence of specific cyclooxygenase-2 inhibitor on TNF-?,IL-6 and expression CD14 positive cells in lupus MRL/lpr mice
- VernacularTitle:特异性COX-2抑制剂对小鼠狼疮性肾炎CD14~+表达及TNF-?、IL-6的影响
- Author:
Qing ZHONG
- Publication Type:Journal Article
- Keywords:
Specific cyclooxygenase-2 inhibitor;
Tumor necrosis factor-?;
Interleukin-6;
Lupus nephritis
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the underlying molecular mechanisms of specific cyclooxygenase-2 inhibitor(Rofecoxib)and to evaluate its efficacy on MRL/lpr mice.Methods:12-week female MRL/lpr mice were given Rofecoxib (10mg?kg -1 ?d -1 )for 12 weeks.Suppressive effect of the drugs on serum and urinary levels of tumor necrosis factor-?(TNF-?),interleukin-6(IL-6) and urinary TXB 2 level were determined by using radio-immunological assay.Changes in proteinuria,serum creatinine,pathology of ltidney and the expression of CD14 in renal tissues were observed.Results:Compared with the ones in the control group,mice treated with Rofecoxib had lower levels of proteinuria( P
