The Analysis of LHbeta -subunit Variants in Infertile Patients with Premature Ovarian Failure (POF) in Korea.
- Author:
Eu Gene LEE
;
Nam Keun KIM
;
Sook Hwan LEE
;
Jung Jae KO
;
Kwang Yul CHA
;
Hye Sun JEON
;
Kyung Ah LEE
- Publication Type:Original Article
- MeSH:
Exons;
Female;
Humans;
Korea*;
Mutation, Missense;
Primary Ovarian Insufficiency*
- From:Korean Journal of Fertility and Sterility
2000;27(2):179-182
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was performed to determine whether the LHbeta -subunit gene missense mutation is present in Korean infertile patients with 46,XX POF women. The variants of LHbeta exon 2 (Trp 8Arg; TGG to CGG and Ile15Thr; ATC ti ACC) were studied in forty-four 46.XX idiopathic POF and 54 nonpregnant women. The LHbeta exon 2 variants were more frequent in POF patients (20.5%) than nonpregnant( 16.7%) women (p>0.05). POF patients with the variant was slightly higher than nonpregnant women with the variant.
