Effects of Aricept on cholinergic system of chronic cerebral hypoperfusion rats
- VernacularTitle:盐酸多奈哌齐对低灌注大鼠中枢胆碱能系统的影响
- Author:
Jing HUANG
;
Yuanwu MEI
;
Lu SUN
- Publication Type:Journal Article
- Keywords:
Cerebral hypoperfusion;
Cholinesterase;
Cholinergic fibres;
Aricept
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Aricept on the level of cholinesterase and the density of cholinergic fibres in cortex of frontal lobe and hippocampus zone in rats undergoing chronic cerebral hypoperfusion rats. Methods One hundred and twelve male SD rats were divided into a normal group, a model group, a saline treatment group (saline, 3mg/kg/day for six weeks) and an Aricept treatment group (Aricept, 3mg/kg/day for six weeks). After six weeks of treatment, all rats were tested with water maze, and then the level of cholinesterase and the density of cholinergic fibres were detected. Results The performance of the rats of the model group with water maze were worse than that of the normal group (P
