Physical training reduces peripheral markers of inflammation in patients with chronic heart failure
- VernacularTitle:运动训练对慢性心力衰竭患者内皮炎性相关因子的影响
- Author:
Wen PENG
;
Xiue ZHANG
;
Bei CHENG
- Publication Type:Journal Article
- Keywords:
Chronic heart failure;
Inflammation;
Endothelial dysfunction;
Adhesion molecules;
Physical training
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of physical training on serum activity of some peripheral inflammatory markers associated with endothelial dysfunction, such as granulocyte macrophage-colony stimulating factor (GM-CSF), macrophage chemoattractant protein-1 (MCP-1), soluble intercellular adhesion molecule-1(sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in patients with chronic heart failure. Methods Forty-eight patients were enrolled and randomly divided into two groups: a training group and a rest group. The patients of both groups were both given conventional internal medicine therapy, and the patients of the training group were given physical training in addition. The serum levels of GM-CSF, MCP-1, sICAM-1 and sVCAM-1 in patients of the two groups were determined with stable chronic heart failure before and after 12 weeks of programmed physical training. At the same time, the motor functional status of chronic heart failure patients was evaluated by using the 6-minute walking test. Results It was shown that the physical training produced a significant reduction in serum GM-CSF, MCP-1, sICAM-1 and sVCAM-1 as well as a significant improvement in performance of the 6-minute walking test. Conclusion The physical training could significantly alleviate the inflammation reaction and improve the motor function of patients with chronic heart failure.
