Identification of irisquinone hydroxypropyl-?-cyclodextrin inclusion compoundand its thermodynamic stability
- VernacularTitle:马蔺子素-羟丙基-?-环糊精包合物的鉴定及热力学稳定性研究
- Author:
Xuenong ZHANG
;
Lihua TANG
;
Xueying YAN
;
Qiang ZHANG
- Publication Type:Journal Article
- Keywords:
irisquinone;
inclusion compound;
lyophilization;
X-ray diffraction (XRD);
differential scanning calorimetry (DSC)
- From:
Chinese Traditional and Herbal Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To parperare and identify the irisquinone-hydroxypropyl-?-cyclodextrin (irisquinone-HP-?-CD) inclusion compound. The inclusion mechanism and mol ratio of irisquinone and HP-?-CD were studied simultaneously. Methods The irisquinone-HP-?-CD was prepared with lyophilization technique. The mol ratio between host and guest moleculars was also researched by molecular gradient and continuing variational methods in inclusion processing. At the same time, the inclusion compound was identified by X-ray diffraction (XRD) and differential scanning calorimetry (DSC) methods, respectively. Results The above-mentioned systems showed the mol ratio of HP-?-CD-irisquinone (2 : 1) and the inclusion compound enhanced remarkably the most solubilization and more combined constant of irisquinone in 25, 35, and 45℃. The lyophilized powder had been formed inclusion compound by identifying. Conclusion It is advantageous to increase the solubilization and to strengthen the stability of irisquinone by preparing inclusion compound.
