Optimization for formulation matrix proportion of Bitongning Patch by uniform design
- VernacularTitle:均匀设计法优选痹痛宁贴剂的处方基质配比
- Author:
Jiyong LIU
;
Qing GU
;
Jinhong HU
;
Jingzhen TIAN
- Publication Type:Journal Article
- Keywords:
Bitongning Patch;
uniform design;
scopolamine;
aconitine;
HPCE
- From:
Chinese Traditional and Herbal Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the prescription matrix proportion of Bitongning Patch and observe its percutaneous absorption in vitro. Methods U6(66) Uniform design was performed to investigate the influence of scopolamine and aconitine in the proportion for 24 h cumulative permeation in vitro. The drug permeation behavior through excised mouse skin was studied with improved Franz diffusion cell. Results With the matrix ratio for PVA: 11.02%, PVP: 29.93%, glyceroh 7.42%, azone: 4.95%, and propanediol: 11.06%, respectively, the Patch had the maximal cumulative permeation amount and cumulative permeation curve coincided with the Higuchi Equation. Conclusion The prescription composition optimized by uniform design meets the requirement of skeleton-controlled transdermal delivery system.
