EXPRESSION OF STAT3 PROTEIN IN THE RETINA OF HAMSTER DURING EARLY POSTNATAL DEVELOPMENT
- VernacularTitle:信号转导子与转录激活子3蛋白在金黄地鼠视网膜生后早期发育过程中的表达
- Author:
Yan ZHANG
;
Enhua YU
;
Meng LIU
- Publication Type:Journal Article
- Keywords:
STAT3 protein;
Retina;
Postnatal development;
Immunocytochemical;
Western blot;
Hamster
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and distribution of STAT3 in the retina during the early development of postnatal hamster. Methods Immunocytochemical method and Western blot analysis were used. Results The expression of STAT3 was found in all layers of the retina in all newborn hamsters,most pronounced in the ganglion cell layer(GCL),the inner plexiform layer(IPL)and the inner area of neuroblastic layer(NBL).With the development,the STAT3 immunoreactivity was gradually restricted in the cytoplasm and the nucleus of the retinal ganglion cells.The result of the Western blot showed that the STAT3 was highly expressed in the first week of postnatal development and then reduced gradually till the lowest point in the adulthood.Conclusion The expression of STAT3 protein may be closely related to the early development of the retina in the postnatal hamster.
