RELATIONSHIPS BETWEEN EXPRESSION OF VEGF, cNOS AND ANGIOGENESIS,CELL PROLIFERATION IN HUMAN HEPATOCELLULAR CARCINOMA
- VernacularTitle:肝细胞癌中血管内皮生长因子和cNOS与血管生成及细胞增殖的关系
- Author:
Dali ZHENG
;
Qingling HUANG
;
Sheng ZHANG
;
Jianyi LIN
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Nitric oxide synthase;
Vascular endothelial growth factor
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationships between the expression of VEGF,its receptor KDR/flk-1,cNOS mRNA and angiogenesis,cell proliferation,metastasis in human hepatocellular carcinoma(HCC). Methods Immunohistochemical analysis using antibodies against VEGF and its kinase insert domain receptor (KDR) was carried out.cNOS mRNA expression in HCC,liver cirrhosis and normal liver tissue was observed by in situ hybridization.CD34 immunostaining was used to measure the microvascular density(MVD)and proliferative index was evaluated by Ki-67 immunostaining. Results The expressions of VEGF and KDR of HCC were significantly related to MVD,proliferation and metastasis of HCC(P
