Research prowess of mesenchymal stem cells for musculoskeletal regeneration
10.3760/cma.j.issn.1673-4181.2013.04.012
- VernacularTitle:间充质干细胞对肌肉骨骼再生的研究进展
- Author:
Shihai YAN
- Publication Type:Journal Article
- Keywords:
Tissue regeneration;
Bone marrow stromal cells;
Cellular therapy;
Cell transplantation
- From:
International Journal of Biomedical Engineering
2013;36(4):239-244,后插5
- CountryChina
- Language:Chinese
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Abstract:
Regenerative therapies in the musculoskeletal system are effective approaches based on the application of suitable cells,biomaterials and cell factors considering age,disease,target tissue,and several environmental factors.Significant development has been undertaken in the last decade,especially in the field of particular multi-potential adult mesenchymal stem cells (MSCs) for regenerative therapies.However,clinical application of such therapies remains in study.In the clinical arena,autologous cells have been harvested,processed,and readministered according to protocols distinct for the target application.As reviewed in this paper,such applications range from simple single-step approaches,such as direct injection of unprocessed or concentrated blood or bone marrow aspirates,to fabrication of engineered constructs by seeding of natural or synthetic scaffolds with cells which proliferated from autologous tissues and propagated under good manufacturing practice conditions (for example,autologous chondrocyte implantation).However,only few of the therapies have been applied in clinic,and none of these treatments has become a standard treatment for an orthopaedic disease up to now.In summary,this review presents the scientific background,current status,and implications of clinical application of MSCs in the musculoskeletal system and provides perspectives for future developments.
