The role of mitochondrial DNA mutation on neurodegenerative diseases.
- Author:
Moon Yong CHA
1
;
Dong Kyu KIM
;
Inhee MOOK-JUNG
Author Information
- Publication Type:Research Support, Non-U.S. Gov't ; Review
- MeSH: Animals; DNA, Mitochondrial/*genetics; Humans; Mitochondria/drug effects/genetics/metabolism; Molecular Targeted Therapy; *Mutation; Neurodegenerative Diseases/drug therapy/*genetics/metabolism; Reactive Oxygen Species/metabolism
- From:Experimental & Molecular Medicine 2015;47(3):e150-
- CountryRepublic of Korea
- Language:English
- Abstract: Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.
