The expression of P53,K-ras and hMSH2 in ulcerative colitis-associated colorectal cancer
- VernacularTitle:溃疡性结肠炎相关性大肠癌P53、K-ras及hMSH2蛋白表达的研究
- Author:
He WANG
;
Yan LI
;
Weiwei ZHANG
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis with dysplasias;
Ulcerative colitis-associated colorectal cancers;
P53;
K-ras;
hMSH2;
Microsatellite instability
- From:
Chinese Journal of Digestion
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). The positive rate of MSI in UC with dysplasia was significantly higher than that in UC (P0.05). The loss of hMSH2 protein expression was not found in UC with dysplasia and UCACRC. Conclusions Both the mutations of P53, K-ras genes and MSI are early events in UCACRC. There is no relationship between MSI and loss of hMSH2 protein expression in (UCACRC).
