Study on expression of FLICE-inhibitory protein in gastric cancer
- VernacularTitle:胃癌组织中细胞FLICE抑制蛋白基因的表达研究
- Author:
Xiaodong ZHOU
;
Jieping YU
;
Honggang YU
- Publication Type:Journal Article
- Keywords:
FLICE-inhibitory protein;
Gastric cancer;
Apoptosis;
Metastasis
- From:
Chinese Journal of Digestion
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of cellular FLICE/caspase-8 inhibitory protein(c-FLIP) in gastric cancer and its possible implications. Methods Forty-eight gastric cancer specimens and their normal counterparts were obtained. Western blot and immunohistochemistry were used to detect protein expression of c-FLIP. Semi-quantitative RT-PCR and TUNEL were used to measure c-FLIP mRNA levels and tissue apoptotic index, respectively. Results Mean levels of c-FLIP mRNA were significantly higher in gastric can-(cer) tissues than those in matched normal tissues (0.59?0.16 vs 0.24?0.13, P
