Protective effect of Danggui Buxue Decoction on the kidney of diabetis rats
- VernacularTitle:当归补血汤对糖尿病大鼠肾组织的保护作用
- Author:
Yingwen ZHANG
;
Dan XIE
- Publication Type:Journal Article
- Keywords:
Danggui Buxue Decoction;
diabetic nephropathy;
transforming growth factor-?_1;
angiotensinⅡ
- From:
Chinese Traditional Patent Medicine
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the protective mechanism of Danggui Buxue Decoction(Radix Astragali,Radix Angelieae Sinensis) on the kidney of diabetic rats. METHODS: The diabetic animal model was made by a single intraperitoneal injection of 60 mg/kg streptozotocin(STZ) and treated with Danggui Buxue Decoction(DBD) or Benazepril. Renal weight/body weight ratio, blood glucose and lipid, urinary albumin and ? 2-microglobin were measured. The renal pathological lesions were also investigated. The expression of TGF-? 1 mRNA in renal cortex as well as Angiotensin Ⅱ(AngⅡ) concentration of plasma and kidney tissue were determined by In situ hybridization and radioimmunoassay after 4,8 weeks of treatment. RESULTS:DBD had equivalent effects with Benazepril in protecting renal function and alleviating pathologic lesions. By means of inhibiting the expression of of TGF-? 1 mRNA. DBD had no effect on renal and plasmaAngⅡ. CONCLUSION:Danggui Buxue Decoction may alleviate kidney lesion and slow down the progression of DN by decreasing the renal expression of TGF-? 1 mRNA.
