Effects of rapid decompression on serum level of cytokines in mice
- VernacularTitle:快速减压对小鼠血清细胞因子水平的影响
- Author:
Guozhong WANG
;
Chunjin GAO
;
Huan GE
- Publication Type:Journal Article
- Keywords:
Rapid decompression;
Decompression sickness;
Mouse;
Cytokine
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of rapid decompression on serum level of IL-1?,IL- 6 and IL-10 in mice and investigate the role of cytokines in the pathogenesis of decompression sickness. Methods Twenty-one mice were randomly divided into rapid decompression group (14 mice) and normal control group (7 mice). Mice in the rapid decompression group were exposed to 600kPa compressed air for 60 minute,which was then rapidly decompressed to normal pressure in one minute. The serum level of IL-1?,IL- 6 and IL-10 was measured by enzyme-linked immuno-sorbent assay in mice in rapid decompression group after decompression and in normal control group. Results There were no significant changes in the serum level of IL-1?,IL- 6 at the 1st hour after decompression in the rapid decompression group when compared to that of and the normal control group. The serum level of IL-1?,IL- 6 in rapid decompression group at the 3rd hour after decompression was significantly higher than that of the normal control group(P