Effect of panaxynol on rat primary cultured neuron injured by H_2O_2
- VernacularTitle:人参炔醇对大鼠原代培养的神经细胞过氧化氢损伤的影响
- Author:
Zejian WANG
;
Hongzhuan CHEN
;
Qingsheng XUE
;
Yang LU
- Publication Type:Journal Article
- Keywords:
panaxynol;
cortical neuron;
H_2O_2;
anti-oxidative enzyme
- From:
Chinese Traditional and Herbal Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the neuroprotective effect of panaxynol on primary cultured cortical neuron against oxidative stress. Methods Viability of panaxynol acted on neuron oxidative stress was monitored by MTT assay and FCM method. Scavenging effects of panaxynol on free radicals were observed in vitro. Effects of panaxynol on SOD activity and GSH-Px, and MDA content in primary neuron injured by H_2O_2 were also determined. Results Panaxynol (2—16 ?mol/L) could dose-dependently protect neuron from oxidative stress induced by H_2O_2; 8 ?mol/L of panaxynol could decrease necrosis and apoptosis rate of neuron significantly (P
